Experimental Organic Chemistry von Philippa B/Moody Cranwell

<p><b>The definitive guide to the principles and practice of experimental organic chemistry - fully updated and now featuring more than 100 experiments</b></p><p>The latest edition of this popular guide to experimental organic chemistry takes students from their first day in the laboratory right through to complex research procedures. All sections have been updated to reflect new techniques, equipment and technologies, and the text has been revised with an even sharper focus on practical skills and procedures.</p><p>The first half of the book is devoted to safe laboratory practice as well as purification and analytical techniques; particularly spectroscopic analysis. The second half contains step-by-step experimental procedures, each one illustrating a basic principle, or important reaction type. Tried and tested over almost three decades, over 100 validated experiments are graded according to their complexity and all are chosen to highlight important chemical transformations and to teach key experimental skills.</p><p>New sections cover updated health and safety guidelines, additional spectroscopic techniques, electronic notebooks and record keeping, and techniques, such as semi-automated chromatography and enabling technologies such as the use of microwave and flow chemistry. New experiments include transition metal-catalysed cross-coupling, organocatalysis, asymmetric synthesis, flow chemistry, and microwave-assisted synthesis. Key aspects of this third edition include:</p><ul><li>Detailed descriptions of the correct use of common apparatus used in the organic laboratory</li><li>Outlines of practical skills that all chemistry students must learn</li><li>Highlights of aspects of health and safety in the laboratory, both in the first section and throughout the experimental procedures</li><li>Four new sections reflecting advances in techniques and technologies, from electronic databases and information retrieval to semi-automated chromatography</li><li>More than 100 validated experiments of graded complexity from introductory to research level</li><li>A user-friendly experiment directory</li><li>An instructor manual and PowerPoint slides of the figures in the book available on a companion website</li></ul><p>A comprehensive guide to contemporary organic chemistry laboratory principles, procedures, protocols, tools and techniques,<i>Experimental Organic Chemistry, Third Edition</i>is both an essential laboratory textbook for students of chemistry at all levels, and a handy bench reference for experienced chemists.</p>

Philippa B. Cranwell, PhD is a Lecturer in the Department of Chemistry, University of Reading, UK. Laurence M. Harwood, PhD is Professor of Organic Chemistry in the Department of Chemistry and Director of the Chemical Analysis Facility, University of Reading, UK. Christopher J. Moody, PhD is Sir Jesse Boot Professor in the School of Chemistry, University of Nottingham, UK.

About the authors ixPreface to the third edition xiAbout the companion website xvPART 1: LABORATORY PRACTICE 11 Safety in the chemical laboratory 31.1 Essential rules for laboratory safety 41.2 Hazardous chemicals 71.3 Disposal of hazardous waste 111.4 Accident procedures 122 Glassware and equipment in the laboratory 152.1 Glass equipment 162.2 Hardware 212.3 Heating 242.4 Stirring 302.5 Vacuum pumps 322.6 The rotary evaporator 422.7 Catalytic hydrogenation 462.8 Ozonolysis 482.9 Irradiation 502.10 Compressed gases 543 Organic reactions: From starting materials to pure organic product 613.1 Handling chemicals 623.2 The reaction 813.3 Purification of organic compounds 1054 Qualitative analysis of organic compounds 1854.1 Purity 1854.2 Determination of structure using chemical methods 2025 Spectroscopic analysis of organic compounds 2075.1 Absorption spectroscopy 2075.2 Infrared spectroscopy 2095.3 Nuclear magnetic resonance spectroscopy 2275.4 Ultraviolet spectroscopy 2795.5 Mass spectrometry 2956 Keeping records: The laboratory notebook and chemical literature 3116.1 The laboratory notebook 3126.2 The research report 3226.3 The chemical literature 327PART 2: EXPERIMENTAL PROCEDURES 329Introduction 331List of experiments 333Experiments that can be taken in sequence 353Experiments that can be used to compare directly different techniques for undertaking a reaction 354Experiments that illustrate particular techniques 3547 Functional group interconversions 3557.1 Simple transformations 3557.2 Reactions of alkenes 3667.3 Substitution 3867.4 Reduction 3907.5 Oxidation 4247.6 Rearrangements 4368 Carboncarbon bond?]forming reactions 4438.1 Grignard and organolithium reagents 4448.2 Enolate anions 4568.3 Heteroatom?]stabilized carbanions 4848.4 Aromatic electrophilic substitution 5048.5 Pericyclic reactions 5148.6 Metal?]mediated coupling reactions 5349 Experiments using enabling technologies 5459.1 Microwave chemistry 5459.2 Flow chemistry 55410 Projects 56910.1 Natural product isolation and identification 56910.2 Project in organic synthesis 57810.3 Aspects of physical organic chemistry 608APPENDICES 627Organic solvents 629Spectroscopic correlation tables 635Index of chemicals 649General index 657

Funktionsweise E-Books.