Colorectal Cancer von Maurizio Ponz de Leon

Colorectal cancer is one of the most frequent human tumors. Despite tremendous advances in our knowledge about the pathogenesis of the disease, the prognosis remains poor for almost half of the individuals affected. This volume provides an updated and comprehensive description of the most relevant features of colorectal cancer - from molecular biology to prevention, from hereditary syndromes to new treatment modalities. It represents an invaluable source for clinicians who deal with colorectal neoplasms and for all those who wish to increase their knowledge of these malignancies.

Inhaltsangabe1 The Causes of Colorectal Cancer.- Descriptive Epidemiology and Temporal Trends.- The Environment and Colorectal Cancer.- Diet and Micronutrients.- Physical Activity, Obesity and Energy Imbalance.- Hormonal Factors.- Smoking and Alcoholic Beverages.- Inflammatory Bowel Diseases.- Drugs.- Colorectal Polyps and the Adenoma-Carcinoma Sequence.- Familial and Hereditary Factors.- Familial Colorectal Cancer.- Hereditary Non-polyposis Colorectal Cancer.- Familial Adenomatous Polyposis.- Gene-Environment Interactions.- Conclusions.- References.- 2 Pathogenesis of Colorectal Cancer.- Main Causes of Colorectal Cancer.- Pathogenesis of Colorectal Cancer: Different Molecular Pathways for One Disease.- Sporadic Colorectal Cancer Development (Loss of Heterozygosity Pathway).- Tumor Development in FAP and Other Polyposis Syndromes.- Colorectal Tumorigenesis in HNPCC (Mutator Genes/Microsatellite Instability Pathway).- The Mitotic Checkpoint Gene Mutation Pathway.- Colorectal Cancer Development in Inflammatory Bowel Diseases.- Tumor Development Through the I1307 K Mutation of the APC Gene: Some Clues to Familial Cancer.- Conclusions.- References.- 3 Pathology of Colorectal Cancer.- The Colorectal Mucosa.- Normal Architecture.- Cell Proliferation.- Aberrant Crypts.- Adenomatous Polyps.- Descriptive Epidemiology.- Distribution, Size and Multiplicity.- Histopathology, Dysplasia and "Malignant Polyps".- Adenomas in Familial Adenomatous Polyposis and Hereditary Non-polyposis Colorectal Cancer.- The Adenoma-Carcinoma Sequence.- Etiology of Adenomatous Polyps.- Other Types of Polyps.- Hyperplastic, Mixed Polyps and Serrated Adenomas.- Flat Adenomas.- Hamartomatous Polyps.- Polyps and Dysplasia in Inflammatory Bowel Diseases.- Other Benign Tumors.- Colorectal Carcinoma.- Adenoma-Carcinoma Sequence Versus "De Novo" Carcinogenesis.- Macroscopic Appearance.- Histological Features and Grading.- Pattern of Metastasis and Staging.- Other Tumors of the Large Bowel.- Conclusions.- References.- 4 Diagnosis and Clinical Features of Colorectal Cancer.- Clinical Findings: Symptoms and Signs.- Laboratory Investigations.- Diagnosis of Colorectal Cancer: Old Methods and Recent Imaging Techniques.- Imaging Studies in Primary Cancer.- Imaging Studies in the Diagnosis of Recurrent or Metastatic Disease.- Conclusions.- References.- 5 Colorectal Cancer Screening and Surveillance.- Colorectal Cancer Screening in the General Population.- Role of Fecal Occult Blood Testing.- Role of Sigmoidoscopy.- Role of Colonoscopy and Barium Enema.- New Screening Procedures Based on Molecular Analysis.- Screening in Individuals with Familial Colorectal Cancer.- Understanding the Nature of the Familial Risk.- Screening Recommendations for Individuals with Familial Risk.- Surveillance After Endoscopic Polypectomy.- Surveillance After Surgery for Colorectal Cancer.- Surveillance in Patients with Inflammatory Bowel Disease.- Surveillance in Hereditary Cancer Syndromes.- Familial Adenomatous Polyposis.- Hereditary Non-polyposis Colorectal Cancer.- Conclusion: Media, Society and Colorectal Cancer Screening.- References.- 6 Prevention and Chemoprevention of Colorectal Neoplasms.- Can We Prevent Colorectal Cancer with an Appropriate Diet?.- Can We Prevent Colorectal Cancer by Modifying Our Lifestyle?.- Secondary Prevention: Is the Removal of Adenomas Effective?.- Colorectal Cancer Prevention Under Special Conditions.- Chemoprevention of Colorectal Cancer.- General Concepts of Chemoprevention.- Main Compounds Used in the Chemoprevention of Colorectal Tumors.- Conclusions.- References.- 7 Treatment of Colorectal Cancer.- Staging Colorectal Neoplasms.- Treatment of Resectable Colorectal Tumors.- Endoscopic Treatment of Malignant Polyps.- Surgical Treatment of Resectable Tumors of the Colon.- Surgical Treatment of Resectable Tumors of the Rectum.- Medical Treatment of Colorectal Tumors.- Radiation Treatment of Rectal Cancer.- Management of Locally Recurrent Cancer.- Treatment of Advanced Colorect

Inhaltsangabe1 The Causes of Colorectal Cancer.- Descriptive Epidemiology and Temporal Trends.- The Environment and Colorectal Cancer.- Diet and Micronutrients.- Physical Activity, Obesity and Energy Imbalance.- Hormonal Factors.- Smoking and Alcoholic Beverages.- Inflammatory Bowel Diseases.- Drugs.- Colorectal Polyps and the Adenoma-Carcinoma Sequence.- Familial and Hereditary Factors.- Familial Colorectal Cancer.- Hereditary Non-polyposis Colorectal Cancer.- Familial Adenomatous Polyposis.- Gene-Environment Interactions.- Conclusions.- References.- 2 Pathogenesis of Colorectal Cancer.- Main Causes of Colorectal Cancer.- Pathogenesis of Colorectal Cancer: Different Molecular Pathways for One Disease.- Sporadic Colorectal Cancer Development (Loss of Heterozygosity Pathway).- Tumor Development in FAP and Other Polyposis Syndromes.- Colorectal Tumorigenesis in HNPCC (Mutator Genes/Microsatellite Instability Pathway).- The Mitotic Checkpoint Gene Mutation Pathway.- Colorectal Cancer Development in Inflammatory Bowel Diseases.- Tumor Development Through the I1307 K Mutation of the APC Gene: Some Clues to Familial Cancer.- Conclusions.- References.- 3 Pathology of Colorectal Cancer.- The Colorectal Mucosa.- Normal Architecture.- Cell Proliferation.- Aberrant Crypts.- Adenomatous Polyps.- Descriptive Epidemiology.- Distribution, Size and Multiplicity.- Histopathology, Dysplasia and "Malignant Polyps".- Adenomas in Familial Adenomatous Polyposis and Hereditary Non-polyposis Colorectal Cancer.- The Adenoma-Carcinoma Sequence.- Etiology of Adenomatous Polyps.- Other Types of Polyps.- Hyperplastic, Mixed Polyps and Serrated Adenomas.- Flat Adenomas.- Hamartomatous Polyps.- Polyps and Dysplasia in Inflammatory Bowel Diseases.- Other Benign Tumors.- Colorectal Carcinoma.- Adenoma-Carcinoma Sequence Versus "De Novo" Carcinogenesis.- Macroscopic Appearance.- Histological Features and Grading.- Pattern of Metastasis and Staging.- Other Tumors of the Large Bowel.- Conclusions.- References.- 4 Diagnosis and Clinical Features of Colorectal Cancer.- Clinical Findings: Symptoms and Signs.- Laboratory Investigations.- Diagnosis of Colorectal Cancer: Old Methods and Recent Imaging Techniques.- Imaging Studies in Primary Cancer.- Imaging Studies in the Diagnosis of Recurrent or Metastatic Disease.- Conclusions.- References.- 5 Colorectal Cancer Screening and Surveillance.- Colorectal Cancer Screening in the General Population.- Role of Fecal Occult Blood Testing.- Role of Sigmoidoscopy.- Role of Colonoscopy and Barium Enema.- New Screening Procedures Based on Molecular Analysis.- Screening in Individuals with Familial Colorectal Cancer.- Understanding the Nature of the Familial Risk.- Screening Recommendations for Individuals with Familial Risk.- Surveillance After Endoscopic Polypectomy.- Surveillance After Surgery for Colorectal Cancer.- Surveillance in Patients with Inflammatory Bowel Disease.- Surveillance in Hereditary Cancer Syndromes.- Familial Adenomatous Polyposis.- Hereditary Non-polyposis Colorectal Cancer.- Conclusion: Media, Society and Colorectal Cancer Screening.- References.- 6 Prevention and Chemoprevention of Colorectal Neoplasms.- Can We Prevent Colorectal Cancer with an Appropriate Diet?.- Can We Prevent Colorectal Cancer by Modifying Our Lifestyle?.- Secondary Prevention: Is the Removal of Adenomas Effective?.- Colorectal Cancer Prevention Under Special Conditions.- Chemoprevention of Colorectal Cancer.- General Concepts of Chemoprevention.- Main Compounds Used in the Chemoprevention of Colorectal Tumors.- Conclusions.- References.- 7 Treatment of Colorectal Cancer.- Staging Colorectal Neoplasms.- Treatment of Resectable Colorectal Tumors.- Endoscopic Treatment of Malignant Polyps.- Surgical Treatment of Resectable Tumors of the Colon.- Surgical Treatment of Resectable Tumors of the Rectum.- Medical Treatment of Colorectal Tumors.- Radiation Treatment of Rectal Cancer.- Management of Locally Recurrent Cancer.- Treatment of Advanced Colorect