UICC Manual of Clinical Oncology von Brian O'Sullivan/Shao Hui Huang/Raphael E Pollock et al

<p>The<i>Manual of Clinical Oncology</i>, Ninth Edition, published with the International Union Against Cancer (UICC), provides a concise, accessible and feasible reference covering state of art multidisciplinary clinical oncology in order to meet the needs of clinicians caring for cancer patients throughout the world.</p><p>Edited by world-renowned practising oncologists and written by key opinion leaders, this book contains authoritative and up-to-date information on cancer detection, diagnosis and treatment alongside topics such as survivorship, special populations and palliative care.</p><p>Remodelled and revised for the ninth edition to provide practical information to oncology workers, the<i>UICC Manual of Clinical Oncology</i> is structured in two parts. Part 1 covers general principles of cancer diagnosis and management with additional attention to special settings in oncology, including supportive care and survivorship, and Part 2 covers site-specific multidisciplinary cancer management. The edition includes up-to-date summaries of all treatment modalities (medical, surgical and radiation) for all tumour sites. It also contains the latest TNM classifications outlined in the<i>TNM Classification of Malignant Tumours</i>.</p><p>The ninth edition includes:<br /><br />Practical presentation with bullet points, tables, and flow charts intended to facilitate quick reference for day-to-day clinical practice in busy oncology environments,<br />Representation of multidisciplinary care for site specific management,<br />Evidence-based approaches to management, including specific treatment recommendations and investigations guided by clinical practice guidelines,<br />State of art evidence-based recommendations that take into consideration the lack of availability of certain medications or resources, as well as practice variations, in different and remote regions of the world, and<br />Contemporary topics on cancer treatment, such as cancer informatics, evidence levels, principles of prognostication, survivorship and cancer in pregnancy.</p><p>Oncologists, oncologists-in-training, nurses working with cancer patients and other health professionals responsible for treating and caring for those with cancers will find the<i>UICC Manual of Clinical Oncology</i> an indispensable and comprehensive resource.</p>

Brian OSullivan, MD, FRCPC, FRCPI, FFRRCSI (Hon), FASTRO (Editor-in-Chief)Professor, Department of Radiation OncologyBartley-Smith / Wharton Chair in Radiation OncologyPrincess Margaret Cancer Centre / University of TorontoToronto, Ontario, CanadaJames D Brierley, BSc, MB, FRCP, FRCR, FRCPC (Associate Editor)Professor, Department of Radiation OncologyPrincess Margaret Cancer Centre / University of TorontoToronto, Ontario, CanadaAnil K. DCruz MS, DNB, FRCS (Associate Editor)Professor, Department of Head and Neck Surgical OncologyTata Memorial Hospital, Mumbai, IndiaMartin F. Fey, MD (Associate Editor)Professor, Department of Medical OncologyInselspital and University HospitalBern, SwitzerlandRaphael Pollock, MD, PhD (Associate Editor)Director of Surgical Oncology, Chief of Surgical ServicesThe James NCICCC/Ohio State UniversityColumbus, OH, USAJan B. Vermorken, MD, PhD (Associate Editor)Emeritus Professor of OncologyFaculty of Medicine and Health Sciences,University of Antwerp, Antwerp, BelgiumDepartment of Medical OncologyAntwerp University HospitalEdegem, BelgiumShao Hui Huang, MD, MSc, MRT(T) (Editorial coordinator)Assistant ProfessorDepartment of Radiation OncologyPrincess Margaret Cancer Centre / University of TorontoBIOGRAPHIESBrian OSullivan is a Professor in the Department of Radiation Oncology at the University of Toronto, Toronto, Ontario, Canada. He also holds the Bartley-Smith/Wharton Distinguished Chair in Radiation Oncology in the Department of Radiation Oncology at the Princess Margaret Cancer Centre, University of Toronto. He is the Head and Neck Oncology Program Chair at Princess Margaret Cancer Centre, the co-Chair of the US NCI Head and Neck Steering Committee, Coordinating Center for Clinical Trials, CTEP, and a full standing member of the Commission of the International Commission on Radiation Units (ICRU). He is the recipient of numerous international awards, and research grants.  He has published almost 300 peer reviewed papers, in excess of 50 book chapters, and has written or edited 6 oncology textbooks.  His interests include sarcoma and head and neck cancer, translational research, IMRT delivery and the principles of image guided radiotherapy, chemo-radiotherapy and molecular targeting. He is a member of the TNM Committee of the Union for International Cancer Control (UICC), Chair of the UICC Prognostic Classification Sub-Committee and represents the UICC as liaison in several oncology sites to the American Joint Committee on Cancer (AJCC).James Brierley is a Professor in the Department of Radiation Oncology at the University of Toronto, Princess Margaret Cancer Centre. He obtained his medical degree from Westminster Medical School, University of London. He initially did postgraduate training in Internal Medicine before transferring to Clinical Oncology. He is interested in the management of gastrointestinal malignancy and thyroid malignancy and cancer staging and surveillance. He has written extensively on thyroid cancer, the role of radiation in gastrointestinal malignancy and cancer staging and surveillance and is actively involved in research into the role of radiation in the management of gastrointestinal and endocrine malignancies and ensuring staging data is collected and used on a population basis. He is the previous head of the Gastrointestinal Site Group at the Princess Margaret Cancer Centre and is currently the Canadian Partnership Against; Cancer  Expert Lead, Staging and Surveillance. He is a Member of the AJCC Executive and Chair of the AJCC Education and Promotions Working Group,  Co-Chair of the UICC TNM Prognostic Factors Core Group and Co-Editor of the UICC 8th edition TNM Classification of Malignant Tumours.Anil DCruz is Director at the Tata Memorial Hospital, Mumbai, India as well as Professor& Surgeon, Department of Head& Neck Surgery.   He is a distinguished leader in the field of oncology and on the Board of Directors of the Union for International Cancer Control (UICC), Geneva, Foundation of Head Neck Oncology India and the Asian Society of Head Neck Oncology.. He has more than 150 peer-reviewed publications and chapters to his name and is also an editor for a two volume text book on Head and neck Surgery. He is Associate Editor of Head Neck Oncology Journal and member of the Editorial Board of many reputed national and international journals. He has delivered more than 250 invited lectures and 50 orations.Martin Fey is a Professor and Head of Department of Medical Oncology at the University of Berne, Switzerland. He is also Head of the Department of Oncology, Laboratory medicine and Hospital Pharmacy at the Inselspital Bern. He received his medical degree from the Berne University Medical School. He was the recipient of Robert-Wenner Award of the Swiss Cancer League and Ellermann Award of the Swiss Society of Haematology. He has more than 250 peer-reviewed publications to his credit, mainly in clinical and experimental haematological oncology. He leads clinical trials in leukaemia, lymphoma, breast cancer and other types of tumours. He was the Chairman of the Leukaemia Group of the Swiss Group for Clinical Cancer Re¬search (SAKK) from 1990-1995 and a Principal Investigator of the SAKK and the International Breast Cancer Study Group (IBCSG) from 1993-2002. His interests include leukaemia, lymphoma, breast cancer, and the design of clinical trials. He is a member of the Cantonal Ethics Committee for Clinical Trials of the Canton of Bern, Switzerland.Raphael Pollock, M.D., Ph.D. was born in Chicago, Illinois and graduated from Oberlin College, Oberlin, Ohio in 1972. This was followed by medical school at the St. Louis University School of Medicine Chicago, IL residencies in General Surgery at the University of Chicago and Rush Medical College, a fellowship in Surgical Oncology at The University of Texas M. D. Anderson Cancer Center, and a Ph.D. in Tumor Immunology from the Graduate School of the Biological Sciences at the University of Texas-Houston Health Sciences Center. Dr. Pollock joined the Department of Surgical Oncology at The University of Texas M. D. Anderson Cancer Center as a faculty member in 1984.  Dr. Pollock became Chairman of the Department of Surgical Oncology in 1993 and became Head of the Division of Surgery at The University of Texas M. D. Anderson Cancer Center in 1997. In 2006-07 Dr. Pollock served as President of the Society of Surgical Oncology; from 1999-2011 he served as Editor-in-Chief of Cancer. In 2013 Dr. Pollock left MD Anderson to become Director and Professor, Division of Surgical Oncology and Chief of Surgical Services at The James Comprehensive Cancer Center at The Ohio State University Medical Center, Columbus, Ohio. Dr. Pollock serves as Director of the Sarcoma Research Laboratory at The Ohio State University Medical Center and is the Principal Investigator on behalf of the US NIH/NCI SARC Sarcoma SPORE grant program. Dr. Pollock is a member of the US NIH/NCI Board of Scientific Counselors.Jan B. Vermorken was born in 1944,  graduated in 1970 from the University of Amsterdam, the Netherlands and became a board-certified specialist in internal medicine in 1975. Since that time he has worked in the field of Medical Oncology and was officially registered as a Medical Oncologist in the Netherlands in 1992. He received his PhD in Medical Sciences in 1986 from the Vrije Universiteit in Amsterdam.  From May 1997 until October 1, 2009, he was Professor of Oncology at the University of Antwerp (UA), and head of the Department of Medical Oncology at the University Hospital Antwerp (UZA), in Edegem, Belgium. After his retirement he remains connected to both University (emeritus Professor) and University Hospital.His main fields of interest are gynecologic oncology, and head and neck oncology. He devotes a significant amount of time to teaching, professional training, and continuing medical education. Professor Vermorken is member of various scientific societies, is member of several editorial boards of International journals, reviewer multiple cancer journals and author or co-author of more than 500 publications in international journals. From January 1, 2009 until January 1, 2014 he was Editor-in-Chief of Annals of Oncology, the official journal of the European Society for Medical Oncology and the Japanese Society of Medical Oncology. On March 1, 2013 he received the title of Commander in the Order of Leopold for his contributions to oncology.

Foreword xPreface xiAbout the Editors xiiiContributors xviPART 1 General principles of cancer diagnosis and management 1Principles of knowledge generation and translation1 Cancer epidemiology 32 Levels of evidence, guidelines and standards 123 Prognosis and classification of cancer 234 Principles of cancer staging 345 Assessment of treatment outcome 406 Cancer informatics 53Principles of cancer diagnosis7 Imaging 638 Pathology 83Principles of treatment9 Principles of surgery 9810 Principles of radiotherapy 10811 Principles of systemic therapy 124Special settings, supportive care and survivorship12 Treatment in pregnancy 13413 Treatment in the elderly 13914 Oncology emergencies 14515 Supportive care during curative treatment 15516 Pain management in cancer 16817 Palliative care 17418 Survivorship 18419 Rehabilitation 194PART 2 Site-specific multidisciplinary cancer management 203Thoracic malignancies20 Lung 205Breast21 Breast 221Gastrointestinal malignancies22 Liver 24123 Biliary tract and pancreas 26323.1 Biliary tract 26323.2 Pancreas 27024 Oesophagus 28025 Stomach 29726 Colon, rectum and anus 30826.1 Colon and rectum 30826.2 Anus 327Genitourinary malignancies27 Prostate 33328 Bladder and other urothelium 34329 Kidney 35430 Testicular germ cell tumours 36831 Penis 384Haematological malignancies32 Lymphoma 39233 Myeloma 41534 Leukaemia 427Gynaecological cancers35 Cervix 44936 Uterus 46737 Ovary and fallopian tube 479Head and neck cancer39 General principles of head and neck cancer management 50340 Nasopharynx 51241 Oral cavity 52442 Larynx and hypopharynx 54243 Oropharynx 55944 Major salivary glands 57145 Nasal cavity and paranasal sinus 58646 Head and neck unknown primary 597Endocrine tumors47 Pituitary 60948 Thyroid 62649 Adrenal tumours 64150 Neuroendocrine tumours 656Dermatological cancer51 Skin: Basal cell carcinoma, squamous cell carcinoma and Merkel cell carcinoma 67452 Melanoma 689Central nervous system and ocular cancers53 Central nervous system 70654 Eye: Choroidal melanoma, retinoblastoma, ocular adnexal lymphSarcoma55 Bone (osteosarcoma) 74556 Soft tissue 754Childhood malignancies57 Paediatric tumors 768Specific cancer situations58 Cancer of unknown primary (no 59 HIV and transplant-related neoplasms 79759.1 HIV-related neoplasms 79759.2 Post-transplantation lymphoproliferative disease 80959.3 Cancer following solid organ transplantation 812Index 815

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